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Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation - AAPS Advances in the Pharmaceutical Sciences Series 7 (Hardback)
  • Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation - AAPS Advances in the Pharmaceutical Sciences Series 7 (Hardback)
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Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation - AAPS Advances in the Pharmaceutical Sciences Series 7 (Hardback)

(editor), (editor)
£149.99
Hardback 317 Pages / Published: 17/09/2013
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Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters' impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

Publisher: Springer-Verlag New York Inc.
ISBN: 9781461482284
Number of pages: 317
Weight: 699 g
Dimensions: 235 x 155 x 23 mm
Edition: 2013 ed.


MEDIA REVIEWS

From the book reviews:

"A collection of chapters from the heavyweights of drug transporters, this book is likely to stand proud on the shelves of anyone in the field. ... The text is very much aimed at those engrossed in the study of transporters and the tools available for their study. ... The latest understanding of transporter-related drug-drug interactions is included, as well as an industrial perspective of transporters in ADME." (Graham Lappin, bts News Magazine of The British Toxicology Society, Issue 1, June, 2014)

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