Total Synthesis of Natural Products with Antimicrobial Activity - Springer Theses (Paperback)
  • Total Synthesis of Natural Products with Antimicrobial Activity - Springer Theses (Paperback)
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Total Synthesis of Natural Products with Antimicrobial Activity - Springer Theses (Paperback)

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£109.99
Paperback 268 Pages / Published: 14/02/2019
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This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.

Publisher: Springer Verlag, Singapore
ISBN: 9789811342455
Number of pages: 268
Weight: 454 g
Dimensions: 235 x 155 mm
Edition: Softcover reprint of the original 1st ed. 201

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