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Therapeutic Antibodies: Methods and Protocols - Methods in Molecular Biology 525 (Paperback)
  • Therapeutic Antibodies: Methods and Protocols - Methods in Molecular Biology 525 (Paperback)

Therapeutic Antibodies: Methods and Protocols - Methods in Molecular Biology 525 (Paperback)

Paperback 585 Pages / Published: 25/11/2014
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Over 2000 years ago in China, antibodies elicited by early forms of vaccination likely played a major role in the protection of the population from infectious agents. Vac- nation has been further developed in Europe and described by Edward Jenner in the late-eighteenth century, then successfully implemented worldwide. The idea to use theactiveingredientinthebloodofvaccinated(orimmunized)animalsorhumansfor the treatment of diseases came a century later. It was made possible by a series of discoveries,suchastherealizationthattheserumfromanimalsimmunizedwithtoxins, for example, diphtheria toxin or viruses, is an effective therapeutic against the disease causedbythesameagentinhumans. Inthe1880s,vonBehringdevelopedanantitoxin (anti-body) that did not kill the bacteria but neutralized the bacterial toxin. The first Nobel Prize in Medicine (1901) was given to him for the discovery of the serum therapy. Acenturylater,22monoclonalantibodies(mAbs)areapprovedbytheUnited States Food and Drug Administration (FDA) for clinical use, and hundreds are in clinicaltrialsforthetreatmentofvariousdiseasesincludingcancers,immunedisorders, and infections. The revenues from the top-five therapeutic antibodies reached $11. 7 billion in 2006, and major pharmaceutical companies raced to acquire antibody biotech companies with a recent example of MedImmune, Inc. , which was acquired for $15. 6 billion by AstraZeneca in 2007. This explosion of research and development in the field of therapeutic antibodies prompted the publication of the MiMB volume Therapeutic Antibodies: Methods and Protocols. The book's major goal is to present a set of protocols useful for researchers discoveringanddevelopingtherapeuticantibodies. Currentadvancesandfuturetrends in the antibody therapeutics are analyzed in the lead-in review article.

Publisher: Humana Press Inc.
ISBN: 9781627038690
Number of pages: 585
Weight: 1275 g
Dimensions: 260 x 193 mm
Edition: 2009 ed.


From the reviews:

"This is an informative and practical handbook for those involved in the discovery and development of therapeutic antibodies. ... Intended for those in the pharmaceutical industry or academia ... and in the offices of those who direct projects which include this type of work. ... This is a valuable addition to the libraries of those who perform day-to-day work in this field, or who manage projects involving therapeutic antibodies. ... this is a valuable guide." (Frederick D. Coffman, Doody's Review Service, June, 2009)

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