The p53 Tumor Suppressor Pathway and Cancer - Protein Reviews 2 (Paperback)
  • The p53 Tumor Suppressor Pathway and Cancer - Protein Reviews 2 (Paperback)
zoom

The p53 Tumor Suppressor Pathway and Cancer - Protein Reviews 2 (Paperback)

(editor)
£139.99
Paperback 246 Pages / Published: 27/11/2014
  • We can order this

Usually despatched within 3 weeks

  • This item has been added to your basket
The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona ?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signi?cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53 ?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the ?eld exploded and p53 became a major focus of scientists around the world.

Publisher: Springer-Verlag New York Inc.
ISBN: 9781489998798
Number of pages: 246
Weight: 403 g
Dimensions: 235 x 155 x 14 mm
Edition: 2005 ed.

You may also be interested in...

The Biology of Cancer
Added to basket
Radical Remission
Added to basket
Medicine Hands
Added to basket
£29.99
Paperback
Cancer: A Very Short Introduction
Added to basket
The Emperor of All Maladies
Added to basket
The End of Your Life Book Club
Added to basket
Oxford Handbook of Oncology
Added to basket
£34.99
Part-work (fascículo)
The Cancer Survivor's Companion
Added to basket
Until Further Notice, I am Alive
Added to basket
Cancer
Added to basket
£12.50
Paperback
Laws of Medicine
Added to basket
Mum's Not Having Chemo
Added to basket
Lecture Notes: Oncology
Added to basket
Nature's Cancer-Fighting Foods
Added to basket

Reviews

Please sign in to write a review

Your review has been submitted successfully.