There is growing evidence that the cell nucleus like the cytoplasm is organized into different functional domains. The best-characterized intranuclear domain is the Nucleolus. This review presents and discusses recent progress in the understanding of nucleolar architecture and its relationship to nucleolar functions. Both the morphology and the composition of the various nucleolar components are analysed during the cell cycle in different eucaryotic organisms. Since controversy is still present in this field, the authors critically evaluate the data and propose a new model of structure-function relationships within the Nucleolus. This review is designed for researchers who need general information on the morphology and functions of the Nucleolus.
Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG