The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors' global contacts and experience with regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widely over the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig's origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. Regulatory aspects of its use are considered.
The reader will find an extensive amount of theoretical and practical information in the pharmacology; ADME and toxicology chapters which will help scientists and managers when deciding which species to use in basic research; drug discovery and pharmacology; and toxicology studies of chemicals, biotechnology products and devices. The book discusses regulatory uses of minipigs in the evaluation of human and veterinary pharmaceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normal laboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in their supply, housing, and transport. The result is an all-inclusive and up to date manual about the experimental uses of the minipig that describes `How to' and `Why' and 'What to expect in the normal', combining enthusiasm and experience with critical assessment of its values and potential problems.
Publisher: Taylor & Francis Inc
Number of pages: 662
Weight: 1822 g
Dimensions: 279 x 216 x 36 mm
"...the breadth and scope of this book extends into other disciplines by exploring mini pigs as a disease model for a myriad of conditions including diabetes mellitus, osteoporosis, atherosclerosis, and oral disease. Wound healing, xenotransplantation, and immunology issues are covered thoroughly as well The text does an excellent job of explaining what is currently known while also highlighting areas where standard protocols are lacking and areas where more research is needed, such as characterizing and sequencing the porcine genome. This may spur further investigations into the biology of mini pigs by increasing researcher confidence and comfort level working with this species in the future."
"Overall, this book will be a very useful reference source on the minipig for anyone involved with this species in biomedical research. lt has elements that will also be of value to toxicologists, and what information is not covered in the book can probably be found through the references provided."
-Guy Healing, AstraZeneca, UK, BTS Newsletter, Issue 41, December, 2012
"This text, The Minipig In Biomedical Research, does an excellent and thorough job of enhancing the merits of the minipig in biomedical research and investigation. The authors underscore the usefulness as well as the shortfalls of the minipig in research as a way to show the laboratory and regulatory community the value and benefits of their use. ... The text is well written, easy to read, and organized in such a way as to make navigation easy for researchers, laboratory technicians, and regulatory personnel."
-Sandra L. Jex, ALN Magazine, April 28, 2012
"... a comprehensive resource ... written by experts in the field ... There is simply no other reference on the topic that offers the depth, detail, bibliographic citations and research connections as does this, making it a unique and top reference for health and science collections alike."
-Midwest Book Review, February 2013
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