Visit our Christmas Gift Finder
The DNA Damage Response: Implications on Cancer Formation and Treatment (Paperback)
  • The DNA Damage Response: Implications on Cancer Formation and Treatment (Paperback)
zoom

The DNA Damage Response: Implications on Cancer Formation and Treatment (Paperback)

(editor), (editor)
£139.99
Paperback 449 Pages / Published: 12/11/2014
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the "DNA damage response". This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.

Publisher: Springer
ISBN: 9789400779952
Number of pages: 449
Weight: 706 g
Dimensions: 235 x 155 x 24 mm
Edition: 2009 ed.

You may also be interested in...

Physics for Clinical Oncology
Added to basket
Cancer: A Very Short Introduction
Added to basket
Diseases of the Breast
Added to basket
£234.00
Hardback
Laws of Medicine
Added to basket
The Cancer Survivor's Companion
Added to basket
Cancer Virus
Added to basket
The Biology of Cancer
Added to basket
B is for Breast Cancer
Added to basket
The Emperor of All Maladies
Added to basket
The End of Your Life Book Club
Added to basket
Improvising Medicine
Added to basket
The Cancer-Fighting Diet
Added to basket

Please sign in to write a review

Your review has been submitted successfully.