Structure-Function Relationship of the Na, K-ATPase - Molecular Biology Intelligence Unit (Hardback)

This text addresses the question, "How does the sodium pump pump?". A variety of primary structure information is available, and progress has been made in the functional characterization of the Na,K-pump, making the answer to this question possible, within reach of currently used techniques. The structure and function of the Na,K-ATPase is reviewed, and relevant information from the study of other P-ATPase is included. Recent results obtained by site-directed mutagenesis are discussed in detail and the book concludes with an integrated model of the molecular mechanisms of Na,K-pump function.