Statistical Methods in Drug Combination Studies - Chapman & Hall/CRC Biostatistics Series (Hardback)
  • Statistical Methods in Drug Combination Studies - Chapman & Hall/CRC Biostatistics Series (Hardback)
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Statistical Methods in Drug Combination Studies - Chapman & Hall/CRC Biostatistics Series (Hardback)

(editor), (editor)
£95.99
Hardback 240 Pages / Published: 11/02/2015
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The growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical methodologies. The theoretical development, coupled with advances in statistical computing, makes it possible to apply these emerging statistical methods in in vitro and in vivo drug combination assessments. However, despite these advances, no book has served as a single source of information for statistical methods in drug combination research, nor has there been any guidance for experimental strategies.

Statistical Methods in Drug Combination Studies fills that gap, covering all aspects of drug combination research, from designing in vitro drug combination studies to analyzing clinical trial data. Featuring contributions from researchers in industry, academia, and regulatory agencies, this comprehensive reference:

Describes statistical models used to characterize dose-response patterns of monotherapies and evaluate the combination drug synergyOffers guidance for estimating interaction indices and constructing their associated confidence intervals to assess drug interactionIntroduces a practical and innovative Bayesian approach to Phase I cancer trials, including actual trial examples to illustrate useExamines strategies in the fixed-dose combination therapy clinical development via case studies stemming from regulatory reviewsEvaluates computational tools and software packages used to apply novel statistical methods in combination drug development

Statistical Methods in Drug Combination Studies provides researchers with a solid understanding of the available statistical methods and computational tools and how to apply them in drug combination studies. The book is equally useful for statisticians to become better equipped to deal with drug combination study design and analysis in their practice.

Publisher: Apple Academic Press Inc.
ISBN: 9781482216745
Number of pages: 240
Weight: 476 g
Dimensions: 235 x 156 x 18 mm


MEDIA REVIEWS

"This book is a welcome addition to the literature and fills a needed niche since last book written on drug synergism was over 15 years ago . . . each chapter presents a different technique for solving common challenges in the development of drug combinations. . . Overall, this book serves as a good reference for both researchers in the field of statistics and drug combination development."
~ Jessica L. Jaynes, California State University, Fullerton

"Investigating drug combinations is a steadily growing area in preclinical and clinical research.As usual, specific statistical methodology is needed to handle these kinds of trials. . . .the book is generallywell structured and the majority of sections actually builds up on and refers to each other. This book provides a good overview on and a good introduction to the topic of statistical methods for drug combination studies, especially regarding the preclinical part."
~ Tim Holland-Letz, German Cancer Research Center Heidelberg

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