Visit our Christmas Gift Finder
Sialo-Xenoantigenic Glycobiology: Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation - Sungkyunkwan University Outstanding Research 1 (Hardback)
  • Sialo-Xenoantigenic Glycobiology: Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation - Sungkyunkwan University Outstanding Research 1 (Hardback)
zoom

Sialo-Xenoantigenic Glycobiology: Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation - Sungkyunkwan University Outstanding Research 1 (Hardback)

(author), (author)
£99.99
Hardback 64 Pages / Published: 02/11/2012
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket

Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid-based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented.

Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN: 9783642340932
Number of pages: 64
Weight: 294 g
Dimensions: 235 x 155 x 6 mm
Edition: 2013 ed.

You may also be interested in...

Pain-Free Biochemistry
Added to basket
Medical Biochemistry at a Glance
Added to basket
Biochemistry For Dummies
Added to basket
How Proteins Work
Added to basket
Oxford Handbook of Medical Sciences
Added to basket
£29.99
Part-work (fascículo)
The Elements of Murder
Added to basket
Immunology
Added to basket
£18.99
Paperback
Biochemistry
Added to basket
£32.99
Paperback
Genetic Analysis
Added to basket
£55.99
Paperback
Essential Physiological Biochemistry
Added to basket
Hormones: A Very Short Introduction
Added to basket
Mathematics for Biological Scientists
Added to basket
BIOS Instant Notes in Biochemistry
Added to basket
Chemistry for the Biosciences
Added to basket
Fundamentals of Biochemical Calculations
Added to basket

Please sign in to write a review

Your review has been submitted successfully.