Screening for Biological Response Modifiers: Methods and Rationale - Developments in Oncology 29 (Paperback)
  • Screening for Biological Response Modifiers: Methods and Rationale - Developments in Oncology 29 (Paperback)
zoom

Screening for Biological Response Modifiers: Methods and Rationale - Developments in Oncology 29 (Paperback)

(author), (author), (author)
£136.00
Paperback 194 Pages / Published: 18/11/2011
  • We can order this

Usually despatched within 3 weeks

  • This item has been added to your basket
The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents. The initial observations stimulated a search for new chemotherapeutic agents which might have increased antitumor activity with less toxicity for normal tissues. To aid in the search for these new chemicals and to attempt to distinguish among the many toxic chemicals which might be candidates for clinical studies, the National Cancer Institute, the pharmaceutical industry, and the cancer research laboratories of most Western nations developed systems for "screening" drugs for antitumor activity. Perhaps the most extensive screening program was established by the National Cancer Institute (1). This screening program has evolved over the last two decades, an evolution which has been repeatedly reviewed (2-5). Various screening programs in use have examined over 500,000 compounds as potential anticancer agents. From these, there are now approximately forty anticancer drugs in clinical use. The utiliy of these compounds and their toxicities have been reviewed on many occasions. It is now apparent that more active and less toxic anticancer drugs are needed. It is also clear that the current screening programs are identifying compounds with similar levels of activity and with continuing moderate to severe toxicity (6).

Publisher: Springer-Verlag New York Inc.
ISBN: 9781461296249
Number of pages: 194
Weight: 332 g
Dimensions: 235 x 155 x 11 mm
Edition: Softcover reprint of the original 1st ed. 198

You may also be interested in...

Radical Remission
Added to basket
Until Further Notice, I am Alive
Added to basket
Cancer Care
Added to basket
£7.99
Paperback
Survival Lessons
Added to basket
Cancer
Added to basket
£12.50
Paperback
The Emperor of All Maladies
Added to basket
Oxford Handbook of Clinical Haematology
Added to basket
£34.99
Part-work (fascículo)
Laws of Medicine
Added to basket
Cancer: A Very Short Introduction
Added to basket
The Cancer Survivor's Companion
Added to basket
Mum's Not Having Chemo
Added to basket
B is for Breast Cancer
Added to basket
How Football Saved My Life
Added to basket
The Cancer-Fighting Diet
Added to basket
The Cancer Chronicles
Added to basket

Reviews

Please sign in to write a review

Your review has been submitted successfully.