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Sample Size Determination in Clinical Trials with Multiple Endpoints - SpringerBriefs in Statistics (Paperback)
  • Sample Size Determination in Clinical Trials with Multiple Endpoints - SpringerBriefs in Statistics (Paperback)
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Sample Size Determination in Clinical Trials with Multiple Endpoints - SpringerBriefs in Statistics (Paperback)

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£54.99
Paperback 95 Pages / Published: 04/09/2015
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This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area.

The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed; if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clinical trials where the alternative hypothesis is that there are effects on ALL endpoints are discussed in detail. The book also briefly examines trials designed with an alternative hypothesis of an effect on AT LEAST ONE endpoint with a prespecified non-ordering of endpoints.

Publisher: Springer International Publishing AG
ISBN: 9783319220048
Number of pages: 95
Weight: 1708 g
Dimensions: 235 x 155 x 6 mm
Edition: 1st ed. 2015


MEDIA REVIEWS
"Sample Size Determination in Clinical Trials with Multiple Endpoints is a new release that will likely be embraced by any statistician involved in the planning of trials with more than one primary outcome. The book comprises much of the authors' original work from recent years ... . Sample Size Determination in Clinical Trials with Multiple Endpoints is a useful complement to the widespread ... sample size books, especially for statisticians interested in designs with coprimary endpoints." (Philip Pallmann, Biometrical Journal, Vol. 59 (1), 2017)

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