Although rare, retinoblastoma has been at the fore- fortunate; while in the developed world eye preser- front of cancer research and treatment for the last tion has become a priority, developing countries c- three decades. The two-hit hypothesis of oncogenesis tinue to face delays in diagnosis, poor access to care, proposed by Alfred Knudson provided the conceptual and suboptimal treatment - the problem in the less framework for tumor suppressor gene research and developed world is cure. led to the discovery of the retinoblastoma pathway as In this book, we have invited a team of experts to a key element in cancer development. More recently, address all those important aspects of retinoblastoma the treatment of children with retinoblastoma has also research and therapy - from biology to epidemiology provided a model for modern approach to the can- to treatment. We hope that in subsequent editions we cer patient; state of the art retinoblastoma treatment will be able to continue to provide updates on such can only be conceived in the context of the multidis- exciting subjects.
Publisher: Springer-Verlag New York Inc.
Number of pages: 156
Weight: 694 g
Dimensions: 244 x 170 x 11 mm
Edition: 2010 ed.
From the reviews:
"This thorough reference, although it covers nearly every imaginable aspect of retinoblastoma, is ... a concise and easy read. ... this book is a wonderful introduction to retinoblastoma for physicians in training. The authors have successfully achieved their goal of compiling a comprehensive book addressing the history, diagnosis, treatment, and future research in this field. ... This is a valuable addition to the literature, providing as it does a single resource that addresses the complexities of treating retinoblastoma." (Christina H. Choe, Doody's Review Service, October, 2010)