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Recent Advances in Glucocorticoid Receptor Action - Ernst Schering Foundation Symposium Proceedings 40 (Hardback)
  • Recent Advances in Glucocorticoid Receptor Action - Ernst Schering Foundation Symposium Proceedings 40 (Hardback)
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Recent Advances in Glucocorticoid Receptor Action - Ernst Schering Foundation Symposium Proceedings 40 (Hardback)

(editor), (editor), (editor)
£199.99
Hardback 380 Pages / Published: 12/09/2002
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Since 1948, hydrocortisone (cortisol), the principal glucocorticoid (GC) of the human adrenal cortex has been successfully used at phar- macological concentrations for the suppression of clinical manifesta- tions of rheumatoid arthritis. Numerous compounds with GC activity have also been developed and used. Fifty years after their initial clinical use, GCs are still the most im- portant and frequently prescribed class of anti-inflammatory drugs for various inflammatory disorders. They are administered either orally, parenterally (intravenous, intramuscular, intrathecal), or topically (cu- taneous, intranasal, pulmonic, rectal). Despite the many beneficial ef- fects of GCs, they also have their limitations and disadvantages that occur with varying prevalence on different organs and after different durations of therapy. These side-effects can range in severity from cos- metic (e.g. telangiectasias, hypertrichosis) to seriously disabling (e.g. induction of glaucoma, diabetes, osteoporosis) or even life-threatening disorders (e.g. gastric haemorrhage). These adverse effects of GCs se- riously handicap their successful use as anti-inflammatory agents. There is therefore a strong need for the development of substances with the anti-inflammatory potency of classical GCs but with reduced side-effects.

Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN: 9783540432296
Number of pages: 380
Weight: 809 g
Dimensions: 223 x 152 mm
Edition: 2002 ed.

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