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Quantitative Pharmacology: An Introduction to Integrative Pharmacokinetic-Pharmacodynamic Analysis (Hardback)
  • Quantitative Pharmacology: An Introduction to Integrative Pharmacokinetic-Pharmacodynamic Analysis (Hardback)

Quantitative Pharmacology: An Introduction to Integrative Pharmacokinetic-Pharmacodynamic Analysis (Hardback)

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Hardback 264 Pages / Published: 07/05/2012
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PKPD awareness is vital if we are to attempt to relate preclinical results to the acute and long term consequences in humans. The debate on whether preclinical findings can be translated to the human usage is still engaging scientists across industry, academia and regulatory bodies. Pharmacokinetics (PK) and pharmacodynamics (PD) comprise traditionally distinct disciplines within pharmacology, the study of the interaction of drugs with the body. It is our intention to show that by deliberately, intimately and systematically integrate these disciplines our understanding of drugs and the efficiency and effectiveness of drug discovery and development may be greatly enhanced. The book is therefore written with a broad audience in mind and focuses on concepts. Pharmacologists of all sorts, safety scientists, pharmacokineticists, medicinal chemists, clinicians, statisticians, veterinarians, animal science professionals, project leaders and students of medical, pharmaceutical and veterinary sciences are the primary targets.

This textbook

Introduces the basics of PK and PD conceptsOutlines the implications of integrating PK and PD analysisIntroduces the principles behind different biomarkers and inter-species scalingDiscusses experimental design of PK, PD and safety studies in non-human speciesCovers numerous real life Case Studies from the drug discovery arena

Publisher: Taylor & Francis Ltd
ISBN: 9781466560314
Number of pages: 264
Weight: 814 g
Dimensions: 239 x 170 x 20 mm


"... provides very attractive and comprehensive reading for a broad audience-inside as well as outside Pharma-with interest in integrating PK and PD observations for greater understanding of how to connect drug fate and treatment consequences in vivo."
-Professor Arvid Carlsson, Nobel Laureate, Gothenburg University

"I consider the book by Gabrielsson and Hjorth to be very useful for in depth studies by scientists working with drug development and experimentalists in clinical pharmacology. It combines the analysis of effects versus time patterns with kinetic corollaries in a most comprehensive way. Moreover, it is a book of great graphical beauty exceptionally styled with a cover painted by one of the authors."
--Gunnar Alvan MD PhD, Emeritus professor and former Director General of the Swedish Medical Products Agency

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