This book provides the framework for a singular reference in the field of pulmonary hypertension. Pulmonary vascular disease is a complex and heterogeneous condition characterized by remodeling of distal pulmonary arterioles that increases pulmonary vascular resistance to affect cardiopulmonary hemodynamic and right ventricular function adversely, resulting in a clinical syndrome of diminished exercise tolerance, shortness of breath, and heart failure-associated morbidity and mortality. Owing to the availability of novel pulmonary circulation-selective pharmacotherapies over the previous decade, the number of pulmonary hypertension patients eligible for treatment has increased substantially. Despite this progress, under-awareness persists within the practicing pulmonary, cardiovascular, and general internal medicine communities. This is due, in part, to the complex array of molecular mechanisms implicated in the pathobiology of PH, as well as cutting-edge discoveries from translational scientific works that provide a new framework by which to understand pulmonary vascular-right ventricular coupling. Taken together, a key educational opportunity is exposed to bridge this knowledge gap through the synthesis of a contemporary text that emphasizes basic science, translational and clinical principles, and treatment strategies for understanding pulmonary hypertension.
Publisher: Springer International Publishing AG
Number of pages: 371
Weight: 1638 g
Dimensions: 279 x 210 x 27 mm
Edition: 1st ed. 2016
"This is a comprehensive book on the important clinical topic of pulmonary hypertension, and one of the most up to date on this emerging field of study. ... The intended audience is specialists in the field of cardiology and pulmonology. ... This book is useful for both clinicians and those interested in basic science and translational research." (Shubhum Misra, Doody's Book Reviews, February, 2016)