Protein Targeting to Mitochondria: Volume 17 - Advances in Molecular & Cell Biology (Hardback)
  • Protein Targeting to Mitochondria: Volume 17 - Advances in Molecular & Cell Biology (Hardback)
zoom

Protein Targeting to Mitochondria: Volume 17 - Advances in Molecular & Cell Biology (Hardback)

(editor)
£76.00
Hardback 355 Pages / Published: 24/02/1997
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
A large number of newly-synthesized polypeptides must cross one or several intracellular membranes to reach their functional locations in the eukaryotic cell. The mechanisms of protein trafficking, in particular the post-translational targeting and membrane translocation of proteins, are of fundamental biological importance and are the focus of intensive research world-wide. For more than 15 years, mitochondria have served as the paradigm organelle system to study these processes. Although key questions, such as how precisely proteins cross a membrane, still remain to be answered, exciting progress has been made in understanding the basic pathways of protein import into mitochondria and the components involved. In addition to a fascinating richness and complexity in detail, the analysis of mitochondrial protein import has revealed mechanistic principles of general significance: Major discoveries include the demonstration of the requirement of an unfolded state for translocation and of the essential role of molecular chaperones on both sides of the membranes in maintaining a translocation-competent conformation and in protein folding after import. It is becoming clear how a polypeptide chain is "reeled" across the membrane in an ATP-dependent process by the functional cooperation of membrane proteins, presumably constituting part of a transmembrane channel, with peripheral components at the trans-side of the membrane. In this volume, eminent experts in the field take the time to review the central aspects of mitochondrial biogenesis. The logical order of the 16 chapters is determined by the sequence of steps during protein import, starting with the events taking place in the cytosol, followed by the recognition of targeting signals, the translocation of precursor proteins across the outer and inner membranes, their proteolytic processing and intramitochondrial sorting, and finally their folding and oligomeric assembly. In addition, the mechanisms involved in the export of mitochondrially encoded proteins as well as recent advances in understanding the division and inheritance of mitochondria will be discussed.

Publisher: Elsevier Science & Technology
ISBN: 9780762301447
Number of pages: 355
Weight: 760 g
Dimensions: 234 x 156 x 22 mm

You may also be interested in...

Molecular Biology of the Gene
Added to basket
Genetic Analysis
Added to basket
£55.99
Paperback
Practical Skills in Biology
Added to basket
Introduction to Bioinformatics
Added to basket
BIOS Instant Notes in Molecular Biology
Added to basket
Exploring Proteins
Added to basket
Giant Molecules
Added to basket
£16.99
Paperback
Thrive in Biochemistry and Molecular Biology
Added to basket
The Nature of the Hydrogen Bond
Added to basket
One Plus One Equals One
Added to basket
Lewin's CELLS
Added to basket
£59.99
Hardback

Reviews

Please sign in to write a review

Your review has been submitted successfully.