Recently there have been many advances in the understanding of the genetic basis of development and regular breakthroughs are being made in the field of tumour cell targeting. Both these areas of research are coming together in terms of their perception of programmed cell death. A broad introduction of the biological significance of cell death is followed by a major review of the significance of physiological cell death in tumours and the factors that influence it. The volume includes a consideration of the role and functions of lymphokines and their bearing on tumour cell targeting and cell killing. The interleukins, interferons and tumour necrotic factor (TNF) are presented in terms of their functional significance rather than in a sequential or systematic manner. This volume concentrates on the bases of biological or programmed cell death. Aspects of necrosis are, however, of necessity covered in comparative and technical terms. The central section on cell death in tumours is followed by a resume of the techniques employed in demonstrating cell death and this section closes with an appendix giving practical details of selected methods.
It is hoped that the book may help potential research workers focus not only on the underlying molecular biology of programmed cell death but also provide impetus for the development of appropriate therapeutic regimes in tumour research.
Publisher: Chapman and Hall
Number of pages: 268
Weight: 1270 g
Dimensions: 235 x 155 mm
Edition: 1990 ed.
...The strengths of this book lie in its eshaustive review of the literature and its solid presentation of those morphological and biochemical features of programmed cell death that distinguish it from necrosis... TIBS; an excellent buy, not only for research but also for clinical pathology laboratories. Cell Biology International Reports; The authors succeeded in giving an excellent overview ... to all ... the monograph can be recommended without restriction - Experimental Pathology; A welcome addition to the available literature . . . quite comprehensive and well presented. The histological an dmorphological information discussed was solid and scholarly. . . . well worth owning. I would especially recommend it to those less familiar with the historical development and basic concepts of programmed cell death. The space devoted to interleukins, cytokines, and immune effector cells will be of interest to immunologists and oncologists alike. The volume will not doubt win over even more enthusiastic supporters of this important biological concept |o Trends in Biochemical Sciences; Timely and valuable as an introduction to this expanding area of cell biology. The authors provide a well-organized overview of the historical background upon which the original concept of programmed cell death is based. . . . should greatly help novices in the field . . . a valuable starting point for individuals newly interested in programmed cell death who wish to be rapidly educated in the basics of the field |o Cancer Cells |d May 1991; Bowen and Bowen should be commended for their coherent, single-handed synopsis on programmed cell death . . . should be useful to students of PCD and to immunobiologists and pathologists interested in tumor regression |o Quarterly Review of Biology |d June '92; The book is filled with impressive amounts of detailed information . . . fine structural studies are addressed . . . The text is most enjoyable to read and reflects an enthusiasm for the study of cell death. . . Ivor and Sandra Bowen have made a valuable addition to the cell death literature |o Cell Proliferation |d Sept 91; ...The strengths of this book lie in its exhaustive review of the literature and its solid presentation of those morphological and biochemical features of programmed cell death that distinguish it from necrosis... TIBS