This book will explore the various aspects of antimicrobial resistance. Despite the remarkable success in the development of potent antimicrobial agents, the emergence of drug resistance remains a major cause for treatment failure. The selection of resistance has been described in viruses, bacteria, parasites, and fungi. However, the underlying molecular mechanisms are highly diverse and depend not only on the microbe, but also on the specific drug (target). Lateral gene transfer in bacteria, selection of mutant variants from viral quasispecies, or drug efflux are prominent examples that illustrate the broad mechanistic spectrum. A major goal of this book project is to discuss and to compare the biological, biochemical, and structural aspects of resistance and its evolution. While predominantly basic in its focus, several chapters of this book will also cover the clinical aspects of antimicrobial resistance. How to test for resistance to optimize therapy? How to minimize or prevent the emergence of resistance and its spread? How to design drugs to preempt the problem of resistance? These are important "practical" questions that can often be linked to mechanistic discussions. Although there are publications that compare the problem of drug resistance associated with different microbes, a comprehensive book that covers and integrates the various aforementioned aspects on this topic would be unique. ai
Publisher: Springer-Verlag New York Inc.
Dimensions: 235 x 155 mm
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