The Testaments out now
Poly(ADP-Ribose) Polymerase: Methods and Protocols - Methods in Molecular Biology 1608 (Hardback)
  • Poly(ADP-Ribose) Polymerase: Methods and Protocols - Methods in Molecular Biology 1608 (Hardback)

Poly(ADP-Ribose) Polymerase: Methods and Protocols - Methods in Molecular Biology 1608 (Hardback)

Hardback 528 Pages / Published: 11/07/2017
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
This book presents multiple new and classical methods for studying the vital poly-ADP-ribose (pADPr) pathway. Beginning with techniques for the detection and quantification of the product of poly(ADP-ribose) polymerase (PARP) enzymatic activity and detection of variation in pADPr production during the cell cycle, the volume continues with sections on the identification of pADPr protein acceptors, methods focusing on studying molecular mechanisms of PARP functions in eukaryotic cells, particularly those involved in control of DNA repair and oxidative stress, as well as in expression regulation, approaches to the in vitro reconstitution of PARP-1 interaction with chromatin, the development and testing of small molecule PARP inhibitors, and the functions of understudied members of PARP family. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Poly(ADP-Ribose) Polymerase: Methods and Protocols, Second Edition serves as an ideal companion to the first edition for scientists whose investigations involve this important pathway.
The chapter 'Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach' is published open access under a CC BY 4.0 license.

Publisher: Humana Press Inc.
ISBN: 9781493969920
Number of pages: 528
Weight: 1622 g
Dimensions: 254 x 178 mm
Edition: 2nd ed. 2017

You may also be interested in...

The Elements of Murder
Added to basket
Thrive in Biochemistry and Molecular Biology
Added to basket
Chemistry for the Biosciences
Added to basket
The Cell: A Very Short Introduction
Added to basket
A Tale of Seven Elements
Added to basket
Mathematics for Biological Scientists
Added to basket
Added to basket
Medical Biochemistry at a Glance
Added to basket
Color Atlas of Biochemistry
Added to basket
Hormones: A Very Short Introduction
Added to basket
BIOS Instant Notes in Biochemistry
Added to basket
Clinical Biochemistry
Added to basket
Pain-Free Biochemistry
Added to basket

Please sign in to write a review

Your review has been submitted successfully.