Phenotypic Variation: Exploration and Functional Genomics (Hardback)
  • Phenotypic Variation: Exploration and Functional Genomics (Hardback)
zoom

Phenotypic Variation: Exploration and Functional Genomics (Hardback)

(author)
£53.00
Hardback 252 Pages / Published: 03/02/2011
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
During the past two decades international collaborative studies have yielded extensive information on genome sequences, genome architecture and their variations. The challenge we now face is to understand how these variations impact structure and function of organelles, physiological systems and phenotype. The goal of this book is to present steps in the pathways of exploration to connect genotype to phenotype and to consider how alterations in genomes impact disease. In this book the author reviews published research in functional genomics carried out primarily since 2006 that sheds light on aspects of phenotypic variation. The goal of functional genomics is to gain insight into mechanisms through which specific changes in genome transcripts and regulation induce changes in proteins, pathways, organelles, cellular and tissue functions, morphology and ultimately in phenotype. Topics reviewed include investigations in genome architecture, gene structure, gene regulation epigenetic modifications and function of organelles including mitochondria, and the endosome lysosome system. New insights into neurodevelopment and neurobehavioral disorders gained through functional genomic research are presented. Aspects of genomic studies in complex common diseases are reviewed. Molecular genetic variations and aberrations in cellular mechanisms involved in protein quality surveillance play a role in late onset diseases and one chapter deals with this topic. Molecular analyses of genes and proteins continue to shed light on the pathogenesis of malformation syndromes and specific examples of such studies are presented. There is growing evidence that late onset disorders such as Parkinson disease, are frequently the end result of defects in functioning of components in different pathways and examples of these are discussed. There is evidence that genetic variation determines differences in response to environmental insults. Genetic variations in complement factor genes are an example of this and are discussed in the context of macular degeneration and pathogenesis of hemolytic uremic syndrome in response exposure to E coli Shiga toxin. In the final chapter the author briefly summarizes key features of the cascade of events that constitute functional genomics.

Publisher: Oxford University Press Inc
ISBN: 9780195379631
Number of pages: 252
Weight: 570 g
Dimensions: 240 x 170 x 20 mm


MEDIA REVIEWS

"Painstakingly curates an impressive swath of very serious science published in [Smith's] field of functional genomics up until 2009, and is modest in its claims about how we can currently apply the findings to medicine." -- European Journal of Human Genetics




"Painstakingly curates an impressive swath of very serious science published in [Smith's] field of functional genomics up until 2009, and is modest in its claims about how we can currently apply the findings to medicine." -- European Journal of Human Genetics


You may also be interested in...

Mutants
Added to basket
£12.99
Paperback
The Seven Daughters Of Eve
Added to basket
Nature via Nurture
Added to basket
£10.99
Paperback
The Violinist's Thumb
Added to basket
£9.99
Paperback
Rosalind Franklin
Added to basket
£10.99
Paperback
Y: The Descent Of Men
Added to basket
Genes: A Very Short Introduction
Added to basket
The Epigenetics Revolution
Added to basket
The Cosmic Serpent
Added to basket
£8.99
Paperback
The Language of the Genes
Added to basket
The Biology of Cancer
Added to basket
Genetics and Genomics in Medicine
Added to basket

Reviews

Please sign in to write a review

Your review has been submitted successfully.