Lessons from Laron Syndrome (LS), 1966-1992: A Model of GH and IGF-1 Action and Interaction Aeres-Serono Symposium, Lisbon, May 1992. - Pediatric and Adolescent Endocrinology 24 (Hardback)Zvi Laron (editor), J. S. Parks (volume editor)
Hardback 368 Pages / Published: 04/05/1993
- Not available
Laron Syndrome (LS) is a disease characterized by resistance to growth hormone (GH) and caused by molecular defects of the GH receptor, leading to a deficiency of insulin-like growth factor-1 (IGF-1) and a significant impairment of growth. The syndrome is a unique human model of a peptide hormone receptor defect and GH-IGFl interaction. It offers the opportunity to study the consequences of long-term IGF-1 deficiency and the role of IGF-1 in growth and metabolism. With the recent biosynthesis of IGF-1 and the initiation of IGF-1 therapy, a new world of basic biological interactions is opening up. This volume brings together leading researchers in genetics, endocrinology, paediatrics, biochemistry, physiology and pharmacology to summarize what is now known about LS, and to discuss the lessons learned from studying and treating this disease since its initial description in 1966. Special features include the demography of LS, and the first data on the long-term IGF-1 treatment of a large group of patients.
Publisher: S Karger AG
Number of pages: 368
Weight: 1040 g
Dimensions: 216 x 138 mm
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