p53 Protocols - Methods in Molecular Biology 234 (Paperback)
  • p53 Protocols - Methods in Molecular Biology 234 (Paperback)
zoom

p53 Protocols - Methods in Molecular Biology 234 (Paperback)

(editor), (editor)
£105.50
Paperback 280 Pages / Published: 10/11/2010
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
Since the discovery of p53 as a tumor suppressor, numerous methods have evolved to reveal the unique structural features and biochemical functions of this protein. Several unique properties of p53 posed a challenge to understa- ing its normal function in the initial phase of its research. The low levels of p53 in normal cells, its stabilization under situations of genotoxic stress, induction of growth arrest, and apoptosis with stabilization of the protein, obstructed the visibility of its normal, unmutated function. The property of p53 that can sense a promoter and transactivate or inhibit is still not well understood. It is still not known whether it is the absence of the protein that causes tumorigenesis, or if its mutants have a dominant role in inducing cancer. p53 Protocols comprises eighteen chapters for the study of the diverse properties of p53 and related proteins. The methods included are invaluable for delineating the function of other proteins that may function as tumor suppr- sors or growth suppressors. The chapters are not presented in any schematic order, for the importance and diversity of the functions of p53 make it imp- sible to organize them suitably. We have made a sincere effort to collect the methods most useful to those investigators working on tumor suppressors or growth suppressors. The purpose of p53 Protocols is not only to provide investigators with methods to analyze similar biochemical functions, but also to familiarize them with the associated problems that arose during the course of investigations.

Publisher: Humana Press Inc.
ISBN: 9781617373619
Number of pages: 280
Weight: 435 g
Dimensions: 229 x 152 x 16 mm
Edition: Softcover reprint of hardcover 1st ed. 2003

You may also be interested in...

How We Live and Why We Die
Added to basket
The Neuron
Added to basket
£74.00
Hardback
The Cell: A Very Short Introduction
Added to basket
Wetware
Added to basket
£16.00
Paperback
Cells to Civilizations
Added to basket
On Growth and Form
Added to basket
Lewin's CELLS
Added to basket
£59.99
Hardback
Stem Cells: A Very Short Introduction
Added to basket
The Machinery of Life
Added to basket
Molecular & Cell Biology for Dummies
Added to basket
The Shaping of Cambridge Botany
Added to basket
Biophysics
Added to basket
£69.99
Hardback
Secret Chambers
Added to basket
£10.99
Paperback
Mathematics for Biological Scientists
Added to basket

Reviews

Please sign in to write a review

Your review has been submitted successfully.