This novel is set at the turn of the twentieth century. When their father dies young, exhausted by the failure of his attempts at agriculture, it is left to the visionary Alexandra to guide the family to prosperity and safeguard the fortune of her brothers. Strong-willed and fiercely independent, she succeeds against all odds, but only at the cost of her own fulfilment as a woman. Central to the novel's action is the Nebraskan landscape it describes, by turns unyielding and fruitful, bitter and ecstatic. "O Pioneers!" joins Cather's "My Antonia in Everyman's Library".