Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. With contributions from an international selection of authors who are leaders in commercial infusion technology, Non-Clinical Vascular Infusion Technology, Volume II: The Techniques provides a current account of the techniques involved in all the major laboratory animal species for conducting successful vascular infusion studies with xenobiotics.
Following in the footsteps of the highly praised Handbook of Pre-Clinical Continuous Intravenous Infusion, this new volume covers both up-to-date procedures and equipment. It is organized by species, including all those commonly used in pre-clinical studies: rat, mouse, dog, minipig, large primate, and marmoset. There are also chapters on juvenile studies and reproductive toxicity studies. Each section addresses the selection of the best model, surgical and non-surgical best practices, practical techniques, equipment selection, and commonly encountered background pathologies.
Using a fresh approach, the authors identify best practices to be shared across the industry, and provide guidance on choices for the most acceptable methodologies from an animal welfare perspective. This volume, along with Volume I: The Science, provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery.
Emphasizes best practices in accordance with the 3Rs-reduction, refinement, and replacement of animal usage in laboratoriesPresents step-by-step procedures and practical tips covering a wide range of common animal models, augmented by the liberal use of illustrationsCovers modern practices and procedures in accordance with up-to-date equipment development
Publisher: Taylor & Francis Inc
Number of pages: 344
Weight: 635 g
Dimensions: 235 x 156 x 24 mm
"These are excellent reference books... a must read for anyone embarking on non-clinical infusion studies for the first time ... I am sure will be found for years to come as well-used inhabitants of the working toxicologist's bookshelf."
-Malcolm Blackwell, Sequani Ltd, UK in bst News
"Owen Green and Guy Healing have shown the importance of the 3Rs in infusion technology at international meetings and in producing this book."
-From the Foreword by Kathryn Chapman, Head of Innovation and Translation, the National Centre for the Replacement, Refinement and Reduction of Animals in Research
Praise for the First Edition, Handbook of Pre-clinical Continuous Intravenous Infusion
" ... an excellent buy for anyone involved in drug development, risk assessment or within drug licensing agencies and in academic research. ... This book represents a benchmark achievement for this technique ... it will become the standard for many years to come."
-British Toxicology Society Newsletter
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