Non-Clinical Vascular Infusion Technology, Two Volume Set: Science and Techniques (Hardback)
  • Non-Clinical Vascular Infusion Technology, Two Volume Set: Science and Techniques (Hardback)

Non-Clinical Vascular Infusion Technology, Two Volume Set: Science and Techniques (Hardback)

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Hardback 520 Pages / Published: 14/01/2014
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Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery and the methodologies for carrying it out are brought together in a comprehensive work, Non-Clinical Vascular Infusion Technology, Two Volume Set: Science and Techniques.

Volume I: The Science covers the scientific principles behind the delivery systems, from both physical and physiological standpoints. It addresses body fluid dynamics, describes the scientific processes necessary to understand the various aspects of the physico-chemical issues relating to vascular infusion delivery, and discusses vascular infusion dynamics. It also considers all the essential elements of the preparation of a formulation intended for vascular delivery as well as assessment of compatibility of the formulation with the dosing apparatus.

Volume II: The Techniques builds upon the highly praised Handbook of Pre-Clinical Continuous Intravenous Infusion and provides a current account of the techniques and equipment involved in all the major laboratory animal species for conducting successful vascular infusion studies with xenobiotics. It is organized by species, including all those commonly used in pre-clinical studies: rat, mouse, dog, minipig, large primate, and marmoset. There are also chapters on juvenile studies and reproductive toxicity studies. Each section addresses the selection of the best model, surgical and non-surgical best practices, practical techniques, equipment selection, and commonly encountered background pathologies.

Using a fresh approach, the authors identify best practices to be shared across the industry, and provide guidance on choices for the most acceptable methodologies from an animal welfare perspective. This two-volume set provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery.

Publisher: Taylor & Francis Inc
ISBN: 9781439874400
Number of pages: 520
Weight: 1157 g
Dimensions: 235 x 156 x 41 mm


"This book provides comprehensive, practice-oriented guidelines for scientists who design and perform studies with vascular drug delivery techniques. I highly recommend this book for both new and experienced scientists who plan to work with, or are already working with, vascular infusion techniques. Weighted numerical score: 96 - 4 stars."
-Ivan Laszlo Csanaky, MD, Ph.D, University of Kansas School of Medicine, Kansas City, USA from Doody's Book Reviews (TM)

"Owen Green and Guy Healing have shown the importance of the 3Rs in infusion technology at international meetings and in producing this book."
-From the Foreword by Kathryn Chapman, Head of Innovation and Translation, the National Centre for the Replacement, Refinement and Reduction of Animals in Research

Praise for the First Edition, Handbook of Pre-clinical Continuous Intravenous Infusion

" ... an excellent buy for anyone involved in drug development, risk assessment or within drug licensing agencies and in academic research. ... This book represents a benchmark achievement for this technique ... it will become the standard for many years to come."
-British Toxicology Society Newsletter

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