New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations - Springer Theses (Hardback)
  • New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations - Springer Theses (Hardback)
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New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations - Springer Theses (Hardback)

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£88.00
Hardback 123 Pages / Published: 30/12/2016
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This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and ,ss-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of ss-substituted nitroalkenes. The scope of Rauhut-Currier reaction was successfully extended to the most challenging ss-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via -addition. Highly enantiopure tetrahydropyridazinones and -amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available ,ss-unsaturated carboxylic acids were first successfully employed to generate the ,ss-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.

Publisher: Springer Verlag, Singapore
ISBN: 9789811028984
Number of pages: 123
Weight: 3376 g
Dimensions: 235 x 155 x 10 mm
Edition: 1st ed. 2017

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