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Cholecystokinin (CCK) is found in high concentrations in mammalian brain where it appears to act as a neurotransmitter. CCK has been implicated in a number of important physiological processes and disease states, including feeding and feeding disorders, nociception, schizophrenia, movement disorders, anxiety, and panic disorder. The recent increase in interest in CCK is mainly attributable to the development of potent selective CCK receptor antagonists. These drugs have proved to be valuable research tools and may also prove useful as therapeutic agents. This volume reviews the most recent data on the role of CCK in normal and abnormal brain function. It brings together contributions from the leading researchers in the field of CCK neurobiology. Particular emphasis is placed on the roles of CCK receptor subtypes (CCKA and CCKB) which have been determined using selective antagonists. This volume reviews the most recent data on the role of CCK in the central nervous system.
Publisher: Oxford University Press
Number of pages: 578
Weight: 996 g
Dimensions: 237 x 163 x 38 mm
'it is a model of how a good, comprehensive text derived from a symposium devoted to a specific topic ought to be produced, in that it has depth, breadth and a sense of the moment ... What this volume also gives credit to is the productive interaction which can take place between industrial and ... academic research ... this book is outstanding, for the cognoscenti it is an impressive snapshot of where CCK is now, while for the uninitiated it is a first class introduction and source book - well worth having in the library.' Philip Winn, Psychologia
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