mTOR Inhibition for Cancer Therapy: Past, Present and Future (Hardback)
  • mTOR Inhibition for Cancer Therapy: Past, Present and Future (Hardback)
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mTOR Inhibition for Cancer Therapy: Past, Present and Future (Hardback)

(editor), (editor), (editor)
£109.99
Hardback 300 Pages / Published: 01/12/2015
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This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs.

Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation.

Publisher: Springer Editions
ISBN: 9782817804910
Number of pages: 300
Weight: 6414 g
Dimensions: 235 x 155 x 21 mm
Edition: 1st ed. 2016

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