Molecular Mechanisms for Repair of DNA: Part B - Basic Life Sciences 5 (Paperback)
  • Molecular Mechanisms for Repair of DNA: Part B - Basic Life Sciences 5 (Paperback)
zoom

Molecular Mechanisms for Repair of DNA: Part B - Basic Life Sciences 5 (Paperback)

(editor)
£92.00
Paperback 425 Pages / Published: 17/11/2012
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
The excision-repair of ultraviolet-induced lesions in DNA involves a recogni- tion and incision step which is followed by excision of the damaged material, DNA repair resynthesis, and sealing of the fmal gap by polynucleotide ligase (e.g. Howard-Flanders, 1968). The initial incision step appears to require an endo- nuclease which is absent in the uvrA and uvrR mutants of E. eoli K12 (Braun et al., Part A of this book). The polAl strains are deficient in DNA polymerase I activity (de Lucia and Cairns, 1969) and are partially deficient in repairing single-strand breaks in DNA (incision breaks) produced by the excision-repair process (Kanner and Hanawalt, 1970; Paterson et al., 1971). Most of the repair of incision breaks which occurs in the polAl strain appears to require DNA polymerase III (Youngs and Smith, 1973b). Thus, both DNA polymerases I and III have been implicated in the DNA repair resynthesis step of the excision-repair process. Masker et al. (1973) have shown that DNA polymer ase 11 (deficient in polB mutants, Campbell et al., 1972) is involved in UV-induced repair replication in toluene-treated cells which lack both DNA polymerase I and normal DNA replication. However, DNA polymerase 11 is probably not involved in a major way in repair processes in vivo, since wild-type or polAl cells which also contain a polR mutation are no more sensitive to UV or X-radiation than the related polB+ strains (Campbell et al., 1972; Youngs and Smith, 1973e).

Publisher: Springer-Verlag New York Inc.
ISBN: 9781468429008
Number of pages: 425
Weight: 676 g
Dimensions: 235 x 155 x 22 mm
Edition: Softcover reprint of the original 1st ed. 197

You may also be interested in...

The Wisdom of Birds
Added to basket
£20.00
Paperback
The Nature of Sex
Added to basket
Birds and People
Added to basket
£40.00
Hardback
Bats
Added to basket
£4.99
Paperback
RSPB Spotlight: Puffins
Added to basket
Where's the Poop?
Added to basket
£6.99
Paperback
Red Kites in the Chilterns
Added to basket
An African Love Story
Added to basket
Gorillas in the Mist
Added to basket
A Dictionary of Animal Behaviour
Added to basket
The Nature of Sex
Added to basket
The Naming of the Shrew
Added to basket

Reviews

Please sign in to write a review

Your review has been submitted successfully.