Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects - Chapman & Hall/CRC Biostatistics Series (Paperback)
  • Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects - Chapman & Hall/CRC Biostatistics Series (Paperback)
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Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects - Chapman & Hall/CRC Biostatistics Series (Paperback)

(editor)
£46.99
Paperback 533 Pages / Published: 22/07/2018
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Is adaptive randomization always better than traditional fixed-schedule randomization? Which procedures should be used and under which circumstances? What special considerations are required for adaptive randomized trials? What kind of statistical inference should be used to achieve valid and unbiased treatment comparisons following adaptive randomization designs?

Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects answers these questions and more.

From novel designs to cutting-edge applications, this book presents several new and key developments in adaptive randomization. It also offers a fresh and critical look at a number of already-classical topics.

Featuring contributions from statisticians, clinical trialists, and subject-matter experts in academia and the pharmaceutical industry, the text:

Clarifies the taxonomy of the concept of adaptive randomizationDiscusses restricted, covariate-adaptive, response-adaptive, and covariate-adjusted response-adaptive (CARA) randomization designs, as well as randomized designs with treatment selectionGives an exposition to many novel adaptive randomization techniques such as brick tunnel randomization, targeted least absolute shrinkage and selection operator (LASSO)-based CARA randomization, multi-arm multi-stage (MAMS) designs, to name a fewAddresses the issues of statistical inference following covariate-adaptive and response-adaptive randomization designsDescribes a successful implementation of a single pivotal phase II/III adaptive trial in infants with proliferating hemangiomaExplores some practical aspects of phase II dose-ranging studies and examines statistical monitoring and interim analysis issues in response-adaptive randomized clinical trials

Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects covers a wide spectrum of topics related to adaptive randomization designs in contemporary clinical trials. The book provides a thorough exploration of the merits of adaptive randomization and aids in identifying when it is appropriate to apply such designs in practice.

Publisher: Taylor & Francis Ltd
ISBN: 9781138893948
Number of pages: 533


MEDIA REVIEWS

"The discussion of the various type of adaptive designs is quite thorough and broad, incorporating many of the recent advances in the field. The book provides an excellent theoretical description of many of the more commonly employed adaptations. ... a valuable resource for researchers and practitioners in adaptive trial design. The book covers a wide range of topics in adaptive randomization, going into depth in a generalized framework that applies to a broad range of trial designs, and also includes some valuable methods on how to put these trials into practice."
-Journal of Biopharmaceutical Statistics, Issue 2, 2016

This is an impressive and useful book, which covers various types of adaptive randomisation
designs and provides a thorough exploration of the merits of adaptive randomisation.

-Lili Zhao, Department of Biostatistics, University of Michigan

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