This volume explores the role of defects in oxidative phosphorylation and oxidative stress in the pathogenesis of neurodegenerative diseases. It describes the relationship between impaired energy metabolism, excytotoxicity and the generation of free radicals. The role of mitochondrial dysfunction in normal aging, and its potential role in the delayed onset of neurodegenerative diseases, as well as the result of animal studies using mitochondrial toxins such as MPTP and 3-nitropropionic acid, are described. The evidence for both dysfunction and oxidative stress in Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis are critically reviewed. Lastly, five different therapeutic approaches to the treatment of neurodegenerative diseases are discussed.
Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG