Visit our Christmas Gift Finder
Click & Collect from 2 Hours
Last Christmas Delivery Dates
Free UK Standard Delivery on orders £20 and over Order in time for Christmas 18th December 2nd Class | 19th December 1st Class Free Click & Collect to shops From 2 hours of your order*
Microencapsulation and Artificial Cells (Hardback)
  • Microencapsulation and Artificial Cells (Hardback)

Microencapsulation and Artificial Cells (Hardback)

Hardback 320 Pages / Published: 15/12/1984
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
Early studies by Pendleton and West (1) in 1932 demonstrated that urea moved from the blood into the small intestine in uremic dogs. In 1946, Twiss and Kolff (2) showed in uremic patients that urea could be removed when an isotonic solution was perfused through an isolated in- testinalloop. Since these early studies had demonstrated the presence of urea and its removal from the gastrointestinal tract, Yatzidis (3) in 1964 investigated the use of activated charcoal for the removal of uremic wastes from the intestinal tract. In addition to Yatzidis' studies with char- coal, other investigations with charcoal have been unable to confirm any significant reduction in serum levels of urea, creatinine, uric acid, or guanidines (4,5) via this approach. At the same time that Yatzidis proposed the use of charcoal for re- moval of nitrogenous wastes from the intestinal tract, he also proposed using charcoal in a hemoperfusion microapparatus as an effective artifi- cial kidney. However, clinical studies performed with the Yatzidis char- coal artificial kidney showed an adverse affect on platelets and the re- lease of embolizing particles (6,7). To overcome these platelet and emboli problems, Chang's group (8) proposed the general idea of "artificial cells," Le., microcapsules con- taining adsorbents. Since the charcoal particles were now encased within blood compatible membranes, they could not leave the microcapsules to cause embolism, and platelets did not now come in direct contact with the charcoal. In their early clinical hemoperfusion studies, Chang et al.

Publisher: Humana Press Inc.
ISBN: 9780896030732
Number of pages: 320
Weight: 1750 g
Dimensions: 254 x 178 x 19 mm
Edition: 1984 ed.

You may also be interested in...

A Dictionary of Biomedicine
Added to basket
Data Handling and Analysis
Added to basket
Biomedical Science
Added to basket
Added to basket


Please sign in to write a review

Your review has been submitted successfully.