Protein posttranslational modification with peptide tags ubiquitin or small ubiquitin-like modifier (SUMO) orchestrate multiple cellular events to ensure normal physiology. These simple enzymatic activities maintain homeostasis of protein modification and normal cell function. This book addresses major proteases - ubiquitin and/or SUMO proteases - involved in posttranslational modification of proteins. Themes reviewed include the difficulty of assigning substrate specificity to the individual de-ubiquitylases (DUBs), selectivity for processing ubiquitin poly-chains, and defining substrate profiles for the different SUMO proteases.
Publisher: Taylor & Francis Ltd
Number of pages: 300
Dimensions: 235 x 156 mm
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