• Sign In / Register
  • Help
  • Basket0
Lead-Seeking Approaches - Topics in Medicinal Chemistry 5 (Paperback)
  • Lead-Seeking Approaches - Topics in Medicinal Chemistry 5 (Paperback)
zoom

Lead-Seeking Approaches - Topics in Medicinal Chemistry 5 (Paperback)

(editor)
£196.50
Paperback 217 Pages / Published: 14/03/2012
  • We can order this

Usually despatched within 3 weeks

  • This item has been added to your basket
High quality leads provide the foundation for the discovery of successful clinical development candidates, and therefore the identi?cation of leads is an essential part of drug discovery. The process for the identi?cation of leads generally starts with the screening of a compound collection, either an HTS of a relatively large compound collection (hundreds of thousands to one million plus compounds) or a more focused screen of a smaller set of compounds that have been preselected for the target of interest. Virtual screening methods such as structure-based or pharmacophore-based searches can complement or replace one of the above approaches. Once hits are identi?ed from one or more of these screening methods, they need to be thoroughly characterized in order to con?rm activity and identify areas in need of optimization. Finally, once fully characterized hits are identi?ed, preliminary optimization through synthetic modi?cation is carried out to generate leads. Parallel optimization of all properties, including biological, physicochemical, and ADME is the most ef?cient approach to the identi?cation of leads. Hit characterization is described in the previous chapter. The focus of this chapter is on hit optimization and the identi?- tion of leads. After a general overview of these processes, examples taken from the literature since 2001 will be used to illustrate speci?c points. There are also a number of excellent reviews covering the lead identi?cation process [1-6].

Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN: 9783642261060
Number of pages: 217
Weight: 361 g
Dimensions: 235 x 155 x 12 mm
Edition: 2010 ed.

You may also be interested in...

Exploring Proteins
Added to basket
Biochemistry for Dummies, 2nd Edition
Added to basket
BIOS Instant Notes in Biochemistry
Added to basket
Oxford Handbook of Medical Sciences
Added to basket
£29.99
Part-work (fascículo)
The Cell: A Very Short Introduction
Added to basket
Biochemistry
Added to basket
£32.99
Paperback
Harpers Illustrated Biochemistry
Added to basket
Hormones: A Very Short Introduction
Added to basket
The Chemistry of Life
Added to basket
Biochemistry
Added to basket
£51.99
Hardback
The Elements of Murder
Added to basket
Mathematics for Biological Scientists
Added to basket
Introduction to Bioinformatics
Added to basket

Reviews

Please sign in to write a review

Your review has been submitted successfully.