JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.
Publisher: Springer Verlag GmbH
Number of pages: 450
Weight: 706 g
Dimensions: 235 x 155 x 24 mm
Edition: 2012 ed.
From the reviews:"This well-illustrated book provides a comprehensive look at the latest basic and clinical developments on the involvement of Jak-Stat pathway in the regulation of cell development, differentiation, proliferation and apoptosis, the malfunctioning of which results in hematopoietic malignancies and cancer. ... The book is well-illustrated with a number of beautiful color figures. ... Molecular biologists, biochemists, cell biologists, and clinical oncologists will find this book useful." (Omer Iqbal, Doody's Review Service, November, 2012)