This fully revised and expanded Third Edition of Ionic Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signalling, structural biology, and molecular biology and genomics. Ionic Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognised authoritative overview of this field used by all neuroscientists.
Publisher: Oxford University Press Inc
Number of pages: 814
Weight: 1528 g
Dimensions: 242 x 181 x 37 mm
Edition: 3rd ed. 2001
The third edition of Ion Channels of Excitable Membranes is markedly expanded, remarkably up to date, and stands as an unmitigated tour de force. Complete and enthusiastic, but not overwhelming, the text builds intuitively from the biophysical roots of the discipline. By maintaining a historical flavor, the reader is cleanly offered the essential ideas and concepts that remain key even as the field evolves. The book remains a resource for practitioners of
the craft and the essential guide to the electrophysiological universe." * Steven A. N. Goldstein, Cell *