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Ion Channels and Disease (Hardback)
  • Ion Channels and Disease (Hardback)

Ion Channels and Disease (Hardback)

Hardback 481 Pages / Published: 20/10/1999
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Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology.

Publisher: Elsevier Science Publishing Co Inc
ISBN: 9780120653102
Number of pages: 481
Weight: 1060 g
Dimensions: 254 x 175 x 27 mm

"...this volume is a gem of large proportion...a most enthusiastic recommendation to any physician interested in the mechanisms of epilepsy." -EPILEPSY RESEARCH (February 2001) Praise for the First Edition "It was a pleasure to read this magnificent book that can be used for teaching and as a desk reference. In short, this is the premier textbook in vitamins and may be used at both the graduate and undergraduate level." -JOURNAL OF OPTIMAL NUTRITION.

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