Intracellular Delivery III: Market Entry Barriers of Nanomedicines - Fundamental Biomedical Technologies 8 (Hardback)
  • Intracellular Delivery III: Market Entry Barriers of Nanomedicines - Fundamental Biomedical Technologies 8 (Hardback)
zoom

Intracellular Delivery III: Market Entry Barriers of Nanomedicines - Fundamental Biomedical Technologies 8 (Hardback)

(editor), (editor)
£149.99
Hardback 453 Pages / Published: 23/12/2016
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new "drugs" will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes and most recently "nanomaterials" have been said to "show promise" but none of these promises have so far been "reduced" to human clinical practice. The focus of this volume is on cancer indication since the majority of published research relates to this application; within that, we focus on solid tumors (solid malignancies). Our aim is critically to evaluate whether nanomaterials, both non-targeted and targeted to specific cells, could be of therapeutic benefit in clinical practice. The emphasis of this volume will be on pharmacokinetics (PK) and pharmacodynamics (PD) in animal and human studies. Apart from the case of exquisitely specific antibody-based drugs, the development of target-specific drug-carrier delivery systems has not yet been broadly successful at the clinical level. It can be argued that drugs generated using the conventional means of drug development (i.e., relying on facile biodistribution and activity after (preferably) oral administration) are not suitable for a target-specific delivery and would not benefit from such delivery even when a seemingly perfect delivery system is available. Therefore, successful development of site-selective drug delivery systems will need to include not only the development of suitable carriers, but also the development of drug entities that meet the required PK/PD profile.

Publisher: Springer International Publishing AG
ISBN: 9783319435237
Number of pages: 453
Weight: 9066 g
Dimensions: 235 x 155 x 29 mm
Edition: 1st ed. 2016

You may also be interested in...

Survival Lessons
Added to basket
Lecture Notes: Oncology
Added to basket
The Biology of Cancer
Added to basket
Added Time
Added to basket
£6.99
Paperback
Cancer Care
Added to basket
£7.99
Paperback
The Emperor of All Maladies
Added to basket
Oxford Handbook of Oncology
Added to basket
£34.99
Part-work (fascículo)
Oxford Handbook of Clinical Haematology
Added to basket
£34.99
Part-work (fascículo)
Laws of Medicine
Added to basket
The Cancer Survivor's Companion
Added to basket
Beating Cancer with Nutrition
Added to basket
Beat Cancer
Added to basket
£14.99
Paperback
Coping with Chemotherapy
Added to basket
Radical Remission
Added to basket
Practical Radiotherapy Planning
Added to basket

Reviews

Please sign in to write a review

Your review has been submitted successfully.