Integration of Pharmaceutical Discovery and Development: Case Histories - Pharmaceutical Biotechnology 11 (Paperback)
  • Integration of Pharmaceutical Discovery and Development: Case Histories - Pharmaceutical Biotechnology 11 (Paperback)
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Integration of Pharmaceutical Discovery and Development: Case Histories - Pharmaceutical Biotechnology 11 (Paperback)

(editor), (editor), (editor), (editor)
£249.99
Paperback 610 Pages / Published: 07/12/2010
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In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.

Publisher: Springer-Verlag New York Inc.
ISBN: 9781441932884
Number of pages: 610
Weight: 973 g
Dimensions: 229 x 152 mm
Edition: Softcover reprint of the original 1st ed. 199

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