During evolution the vertebrate head has acquired a number of unique features including specialized paired sense organs and cranial sensory ganglia. These evolutionary novelties arise from discrete thickenings of the head ectoderm known as cranial placodes. They include the adenohypophyseal, olfactory, lens, trigeminal, profundal, otic, epibranchial and lateral line placodes. While distinct in the derivatives and cell types they will form, all cranial placodes originate from a common preplacodal domain surrounding the anterior neural plate. Recent evidence suggests that the induction of this pre-placodal domain and its subsequent subdivision into individual placodes with specific identities is a multi-step process. Here we describe the development of these placodes and their derivatives and summarize recent advances in the characterization of the repertoire of transcription factors underlying their development. We also review recent studies that have started to address the role of several classes of signaling molecules in placode induction and segregation, including Bone Morphogenetic Proteins, Fibroblast Growth Factors and Wnt molecules.
Publisher: Morgan & Claypool Publishers
Number of pages: 83
Weight: 171 g
Dimensions: 235 x 187 x 4 mm
You may also be interested in...
Please sign in to write a review
Simply reserve online and pay at the counter when you collect. Available in shop from just two hours, subject to availability.
Thank you for your reservation
Your order is now being processed and we have sent a confirmation email to you at
When will my order be ready to collect?
Following the initial email, you will be contacted by the shop to confirm that your item is available for collection.
Call us on or send us an email at
Unfortunately there has been a problem with your order
Please try again or alternatively you can contact your chosen shop on or send us an email at