Hepatitis C Protocols - Methods in Molecular Medicine 19 (Paperback)

Johnson Y. N. Lau (editor)

£44.99

Paperback 621 Pages
Published: 21/08/2013

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Synopsis

The identification of hepatitis C virus by Michael Houghton and his c- leagues at the Chiron Corporation nearly years ago represented a technical tour de force of modern molecular medicine. This breakthrough not only unearthed the causative agent of non-A non-B hepatitis that had eluded the best of scientists for more than 20 years, but also was symbolic of another chapter in the changing paradigm of modern science and medicine. The re- lutionary concept of identifying a pathogen without actually visualizing or detecting it will forever redefine the way we approach pathogenesis of d- eases whose cause is unknown. It is benefitting that this discovery treads on the heels of the human immunodeficiency pandemic, and parallels the ala- ing emergence of various microbial pestilences in the world. Despite the rapid advances in our understanding of the virus, there is much remaining to learn about it. This book highlights some of the important areas yet to be unraveled. As illustrated in this book, the marriage between basic science and clinical medicine is essential in our quest for these unknowns. The last decade has focused on the fundamentals of the virus; the next decade must underscore translational research, bridging clinical medicine and basic science with re- ization of fundamental knowledge to improve prevention, diagnosis, and tre- ment of viral hepatitis C.

Publisher: Humana Press Inc.
ISBN: 9781489943484
Number of pages: 621
Weight: 930 g
Dimensions: 229 x 152 x 33 mm
Edition: Softcover reprint of the original 1st ed. 199

MEDIA REVIEWS

"Many leading researchers in the field are included in the book. . .It describes state-of-the-art methods and tools that are being used to address important medical and scientific questions. . .not only a highly practical manual for people working in laboratory medicine. . .also valuable for virologists, gastroenterologists, hepatologists and other medical infectious disease specialists."-Infection

"The useful clinical methods sections include description of methods for the detection of antibodies to HCV, quantitative HCV serum RNA assays, polymerase chain reaction (PCR) assays for the detection of HCV in liver and other tissues, HCV genotyping methods, and detection of HCV by in situ hybridization....Additional sections describe methods used by research, development, and production laboratories to clone and express HCV genes, to study viral replication and viral protein function, to produce recombinant HCV proteins, and to create in vitro culture models to allow study of viral replication and possible anitiviral compounds....The "Notes" sections will be particularly useful to individuals setting up the method for the first time. All the chapters contain current information and are well written....the scope of the book of use to anyone desiring to expand his or her knowledge of HCV. The introductory material for the sections is the best compilation of HCV-related information available in print today and makes Hepatitis C Protocols a valuable addition to the published literature on HCV."-Laboratory Medicine

"In summary Johnson Yiu-Nam Lau should be applauded for assembling an outstanding international ensemble of experts to produce a truly authoritative handbook for HCV clinicians and researchers."-The Quarterly Review of Biology

". . . an excellent review of the current and most up-to-date methods in molecular medicine involving hepatitis C. . . clinicians should review this textbook to give them a better understanding of the molecular techniques and shortcomings of the various diagnostic assays that they use in their day to day practice."-Canadian Journal of Infectious Disease