• Sign In / Register
  • Help
  • Basket0
The books you love, the emails you want
Time is running out, opt in before 25 May or you'll stop hearing from us
Yes Please
Genome Stability and Human Diseases - Subcellular Biochemistry 50 (Hardback)
  • Genome Stability and Human Diseases - Subcellular Biochemistry 50 (Hardback)
zoom

Genome Stability and Human Diseases - Subcellular Biochemistry 50 (Hardback)

(editor)
£199.99
Hardback 340 Pages / Published: 18/12/2009
  • We can order this

Usually despatched within 3 weeks

  • This item has been added to your basket

Check Marketplace availability

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting `bottlenecks' in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations.

This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Publisher: Springer
ISBN: 9789048134700
Number of pages: 340
Weight: 760 g
Dimensions: 235 x 155 x 25 mm
Edition: 2010 ed.

You may also be interested in...

The Biology of Cancer
Added to basket
Screening
Added to basket
£49.49
Paperback
The Violinist's Thumb
Added to basket
£9.99
Paperback
Genetics, revised edition
Added to basket
A Dictionary of Genetics
Added to basket
The Compatibility Gene
Added to basket
Epigenetics
Added to basket
£12.99
Paperback
Muscular Dystrophy
Added to basket
Duchenne Muscular Dystrophy
Added to basket
Principles of Psychiatric Genetics
Added to basket
Monkeyluv
Added to basket
£9.99
Paperback
Inheritance
Added to basket
£18.99
Hardback

Reviews

Please sign in to write a review

Your review has been submitted successfully.