Genetic Susceptibility to Cancer - Developments in Oncology 79 (Hardback)Seymour Garte (author)
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A number of `cancer families', in which several closely related individuals have suffered from various specific forms of cancer, have been studied by genetic epidemiologists. However, for the majority of cancer cases, little or no discernible genetic influence or family history is found. Recent research has discovered that for many of these `sporadic' (non-familial) cancer cases, defects or aberrations in certain metabolic genes not previously associated with genetic cancer risk may contribute to either causing the disease or at least increasing the chances of developing cancer. It is therefore possible that much of what has previously passed for `bad luck' may turn out to be a new type of `bad genes'.
Genetic Susceptibility to Cancer explains that this new idea of `bad genes' may contain an unexpected positive side. The carcinogenic effects of these metabolic genes, unlike those of the oncogenes and tumor suppressor genes that are responsible for the inherited cancer syndromes, can potentially be overcome or nullified.
Genetic Susceptibility to Cancer will provide a valuable reference for health professionals, researchers, clinicians and biomedical scientists who are interested in the current thinking in this critically important area of cancer management.
Number of pages: 137
Weight: 870 g
Dimensions: 235 x 155 x 9 mm
Edition: 1998 ed.