The Testaments out now
Gadd45 Stress Sensor Genes - Advances in Experimental Medicine and Biology 793 (Paperback)
  • Gadd45 Stress Sensor Genes - Advances in Experimental Medicine and Biology 793 (Paperback)
zoom

Gadd45 Stress Sensor Genes - Advances in Experimental Medicine and Biology 793 (Paperback)

(editor), (editor)
£89.99
Paperback 134 Pages / Published: 23/08/2016
  • We can order this

Usually dispatched within 3 weeks

  • This item has been added to your basket
Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.

Publisher: Springer-Verlag New York Inc.
ISBN: 9781493953905
Number of pages: 134
Weight: 2292 g
Dimensions: 235 x 155 x 8 mm
Edition: Softcover reprint of the original 1st ed. 201

You may also be interested in...

Medical Genetics at a Glance
Added to basket
Oxford Handbook of Medical Sciences
Added to basket
£32.99
Part-work (fascículo)
Autonomy and Trust in Bioethics
Added to basket
Genes: A Very Short Introduction
Added to basket
£8.99   £7.99
Paperback
Epigenetics
Added to basket
£12.99
Paperback
The Science of Human Perfection
Added to basket
The Violinist's Thumb
Added to basket
£9.99
Paperback
The Compatibility Gene
Added to basket
The Biology of Cancer
Added to basket

Please sign in to write a review

Your review has been submitted successfully.