"Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased production or absence of said hormone. " With these words, Fuller Albright began his now classic paper describing a novel disease, pseudo hypoparathyroidism (PHP), and a novel concept, hormone resis- tance as a cause of disease. Soon, other hormone resistance disorders such as nephrogenic diabetes insipidus (NDI) were recognized, and the concept was extended to resistance to other substances such as calcium ions in familial hypocalciuric hypercalcemia (FHH). Later, diseases characterized by excess rather than deficient hormone action such as McCune-Albright syndrome (MAS) and familial male precocious puberty (FMPP) were recognized to be caused by autonomous endocrine hyperfunction. Although many i!!vestigators provided careful and detailed descriptions of the clinical features of these and other related endocrine disorders, an understanding of pathogenesis proved elusive for many years. In just the past few years, we have gone from clinical description to a molecular understanding of these interesting disorders.
This remarkable progress reflects a synthe- sis of three distinct, but now overlapping, areas of biomedical research: the aforemen- tioned recognition and careful clinical description of specific diseases, the elucidation of the basic mechanisms of signal transduction, and the application of the powerful tools of molecular biology and genetics. Fundamental studies on the mechanisms of hormone action by Rodbell and colleagues at NIH culminated in the discovery of a major signal transduction pathway involving heterotrimeric G proteins.
Publisher: Humana Press Inc.
Number of pages: 324
Weight: 1910 g
Dimensions: 254 x 178 x 20 mm
Edition: 1998 ed.
Winner of one of the Best 1998 Health Sciences Books Awards!
"The book meets the stated objective. . .[of] providing the reader with a complete review of the known molecular and genetic details of the G protein signal cascade and related diseases. . .Each chapter is truly a state-of-the-art description."4 Stars!-Doody's Health Sciences Book Review Journal
"...attractive in its presentation and well illustrated with good quality photographs. . .bibliographies are current and extensive. . .a pleasure to read. . .would complement every medical library and should be highly recommended to clinical and basic scientists."-European Journal of Endocrinology
"G Proteins, Receptors, and Disease is a volume worthy of a place on the bookshelf of anyone with a current interest in endocrine disease and GPCR-targeted approaches to therapeutics....it is refreshing to find a book that communicates just how much genomics-based research can accelerate understanding, not just of a discrete area of science, but of human disease."- Nature Medicine