G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders - Neuromethods 31 (Paperback)
  • G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders - Neuromethods 31 (Paperback)
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G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders - Neuromethods 31 (Paperback)

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Paperback 433 Pages / Published: 16/08/2013
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The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G,, G,, G,, and G12.

Publisher: Humana Press Inc.
ISBN: 9781489942906
Number of pages: 433
Weight: 652 g
Dimensions: 229 x 152 x 23 mm
Edition: Softcover reprint of the original 1st ed. 199

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