Recent advances in the molecular biology of the skin have helped to elucidate the pathological processes resulting in skin disorders. This timely publication brings together the latest data on the molecular events underlying dermatological diseases. New insights into such disorders as ichthyosis, epidermolysis bullosa and photoaging, as well as acute promyelocytic leukemia, are presented. The book also focuses on the role of steroids and retinoids in modulating normal and pathological epithelial differentiation. Special emphasis is given to the steroid/retinoid hormone receptor super-family and its role in pathogenesis and control of gene transcription. Finally, new approaches to therapy are explored, either by targeting a drug to a given receptor that specifically modulates gene expression and differentiation, or by using gene transfer technology to supplement the expression of a deficient gene.
Publisher: S Karger AG
Number of pages: 196
Weight: 640 g
Dimensions: 216 x 138 mm
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