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Fragment-Based Methods in Drug Discovery - Methods in Molecular Biology 1289 (Paperback)
  • Fragment-Based Methods in Drug Discovery - Methods in Molecular Biology 1289 (Paperback)
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Fragment-Based Methods in Drug Discovery - Methods in Molecular Biology 1289 (Paperback)

(editor)
£85.50
Paperback 230 Pages / Published: 05/10/2016
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This volume covers the techniques necessary for a successful fragment-based drug design project, beginning from defining the problem in terms of preparing the protein model, identifying potential binding sites, and the consideration of various candidate fragments for simulation. The second part discusses the technical aspects that various methods have used to simulate fragment binding to a target protein by using Monte Carlo, molecular dynamics, and docking algorithms. After simulations, fragments are assembled into molecules using a variety of approaches, which are explored next. A discussion of design strategies and consideration of drug-like properties is included as part of the design process at this stage. Finally, several examples of successful fragment-based drug design projects are presented. Written for the Methods in Molecular Biology series, this work contains the kind of detailed description and implementation advice to encourage success in the lab.

Practical and cutting-edge, Fragment-Based Methods in Drug Discovery takes into account the great accomplishments in the field to provide an ideal guide for researchers continuing to investigate this exciting area of pharmacological study.

Publisher: Humana Press Inc.
ISBN: 9781493946143
Number of pages: 230
Weight: 5125 g
Dimensions: 254 x 178 mm
Edition: Softcover reprint of the original 1st ed. 201

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