Endothelial Function in Hypertension (Hardback)
  • Endothelial Function in Hypertension (Hardback)
zoom

Endothelial Function in Hypertension (Hardback)

(editor), (editor)
£72.00
Hardback Published: 04/08/1997
  • Not available

This product is currently unavailable.

  • This item has been added to your basket
In 1980, Furchgott and Zawadzki demonstrated that the ability of a blood vessel to relax to acetylcholine is entirely dependent upon the presence of an intact endothelium b1. This startlingly simple and elegant observation heralded a decade of basic research into endothelium-derived vasoactive factors (EDRF). Initially, interest focused on Furchgott's endothelium-derived relaxing factor, which was later identified as the extremely simple molecule, nitric oxide [21. However, bioassay systems suggested the presence of other dilator and constrictor factors. Many of these additional putative factors remain elusive but one constrictor factor was revealed to the world in an impres- sively complete piece of science published in 1988. Yanagisawa, Masaki and colleagues [31 demonstrated the synthesis of a twenty one amino acid peptide which accounted for the constrictor activity found in the supernatant of endothelial cells. They identi- fied its structure, synthesised the peptide, showed its biological activity in vitro and in vivo, proposed mechanisms of action and cloned and sequenced the gene. They named the factor endothelin. The identification of nitric oxide and endothelin has also rekindled interest in established endothelium-derived mediators, including the prostanoids and other arachidonic acid metabolites, and has led to exploration of the possible roles of oxygen radicals such as superoxide. The vascular endothelium has become a major focus for research into disease states or cardiovascular risk factors associated with abnormal vascular tone or reactivity, alterations in cellular adhesion to the vessel wall, increased smooth muscle cell growth and the chronic process of atherogenesis.

Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN: 9783540629436
Weight: 380 g
Dimensions: 235 x 155 mm

You may also be interested in...

Park's The Pediatric Cardiology Handbook
Added to basket
The ECG In Practice
Added to basket
£27.99
Paperback
ECG Pocketcard
Added to basket
Bbp
£2.49
Cards
Heart Disease
Added to basket
£9.99
Paperback
Making Sense of Echocardiography
Added to basket
The HeartMath Solution
Added to basket
ECG Pocket
Added to basket
£8.99
Paperback
Oxford Handbook of Cardiology
Added to basket
£34.99
Part-work (fascículo)
Bennett's Cardiac Arrhythmias
Added to basket
ECGs for the Emergency Physician 1
Added to basket
DASH Diet For Dummies
Added to basket
Blood Chemistry and CBC Analysis
Added to basket
Cardiology
Added to basket
£31.99
Paperback
The ECG Workbook
Added to basket
£28.00
Paperback

Reviews

Please sign in to write a review

Your review has been submitted successfully.